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目的探讨糖尿病病程、BMI、WC、慢性并发症严重程度、HbA_1c等对成年男性2型糖尿病(T2DM)患者血浆总睾酮(TT)水平的影响。方法随机收集106例成年男性T2DM患者的临床资料,并测定血浆TT。对糖尿病慢性并发症的严重程度进行定量评分。采用Pearson相关分析法,评价病程、BMI、WC、慢性并发症、HbA_1c、hsC-RP、血脂对TT的影响。结果成年男性T2DM患者TT水平和年龄、病程、HbA_1c无显著性相关(P均>0.05)。慢性并发症评分较高、WC较大的患者,TT水平降低(P均<0.05)。TC(P>0.05)和LDL-C(P<0.05)水平较高者,TT水平升高。结论慢性疾病、向心性肥胖和机体炎症状态可能引起TT水平下降,且在降脂治疗时应注意TT水平的变化。
Objective To investigate the effects of diabetes course, BMI, WC, the severity of chronic complications and HbA 1c on the plasma total testosterone (TT) in adult male patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 106 adult male patients with T2DM were randomly collected and the plasma TT was measured. The severity of chronic complications of diabetes quantitative score. Pearson correlation analysis was used to evaluate the influence of disease duration, BMI, WC, chronic complications, HbA 1c, hsC-RP and blood lipid on TT. Results There was no significant correlation between TT level and age, course of disease and HbA 1c in adult male patients with T2DM (all P> 0.05). Chronic complications score higher, WC larger patients, TT levels decreased (P all <0.05). TC (P> 0.05) and LDL-C (P <0.05) higher levels, TT levels increased. Conclusion Chronic diseases, concentric obesity and inflammatory status may cause the decrease of TT level, and attention should be paid to the changes of TT level during lipid-lowering therapy.