观察米非司酮对子宫肌瘤的治疗作用及用药前后性激素和子宫内膜的改变。２８例子宫肌瘤病人从月经第２天开始口服米非司酮２５ｍｇ／ｄ，连服３个月，用药前和停药后比较，２８例病人用药后均出现闭经，临床症状消失，贫血改善，肌瘤体积缩小５８％，血清Ｐ升高（Ｐ＜０．０５），处于卵泡期水平，血清ＦＳＨ、ＬＨ、ＰＲＬ、Ｅ２、Ｔ无明显改变，子宫内膜腺体萎缩，缺乏分泌现象，基质中空泡增多，ＥＲ增多，ＰＲ减少。米非司酮治疗子宫肌瘤有一定疗效。 To observe the therapeutic effect of mifepristone on uterine fibroids and changes of sex hormones and endometrium before and after treatment. 28 cases of uterine fibroids patients from the first day of menstruation began oral administration of mifepristone 25mg / d, and even for 3 months, before and after discontinuation of medication, 28 patients were treated with amenorrhea, clinical symptoms disappeared, anemia improved (P <0.05), at the level of follicular stage, serum FSH, LH, PRL, E2, T had no significant change, the endometrial glands atrophy, the lack of secretion, Increased matrix vacuoles, ER increased, PR decreased. Mifepristone treatment of uterine fibroids have a certain effect.