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目的全面了解我院药物不良反应(ADR)发生的情况及一般规律,指导临床合理用药,减少ADR的发生。方法收集ADR报告表526例,按报告表中患者的性别、年龄、怀疑药品、给药途径、ADR累及部位等进行归类统计并分析。结果 526例ADR报告表中药品共12类73种,其中抗感染药引发的ADR的比例为45.1%,所占比例最高;中药注射剂占16.3%次之;静脉给药途径产生ADR的比例最大,达到84.6%;比较容易观察的ADR如皮肤及其附件损害比较常见占42.8%。结论临床医师、护师、药师都应加强ADR监测和上报,做到可疑即上报,以此来减少ADR的发生,增加临床用药的安全性,确保广大群众用药安全。
Objective To comprehensively understand the occurrence and general rules of ADR in our hospital, to guide clinical rational use of drugs and to reduce the occurrence of ADR. Methods 526 cases of ADR were collected and classified according to the sex, age, suspected drugs, route of administration, ADR involved sites in the report form. Results Among the 526 ADR cases, 73 kinds of drugs were found in 12 categories, of which 45.1% were ADR caused by anti-infectives, 16.3% were Chinese traditional medicine injection, followed by intravenous route with the highest proportion of ADR. Up to 84.6%. Easier to observe ADR, such as skin and its accessories, accounted for 42.8%. Conclusion Clinicians, nurses and pharmacists should strengthen the monitoring and reporting of ADR, report suspiciously so as to reduce the incidence of ADR, increase the safety of clinical medication and ensure the safety of the general public.