系统性红斑狼疮 (SLE)是一种常见的自身免疫性疾病 ,常累及多系统、多器官 ,血清出现多种自身抗体 ,并伴有明显的免疫功能紊乱。由于SLE的确切病因与发病机制迄今不详 ,给SLE临床早期诊断和治疗造成很大困难[1,2 ] 。因此 ,尽快阐明SLE的确切病因与发病机理对于制定新的更有效 Systemic lupus erythematosus (SLE) is a common autoimmune disease, often involving multiple systems, multiple organs, serum multiple autoantibodies, accompanied by significant immune dysfunction. Because of the exact etiology and pathogenesis of SLE so far unknown, to SLE early clinical diagnosis and treatment caused great difficulties [1,2]. Therefore, as soon as possible to clarify the exact etiology and pathogenesis of SLE for the development of a new more effective