论文部分内容阅读
目的:探讨台山地区正常孕妇早、中、晚孕期的促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)参考区间。方法:对非妊娠215例、孕期210例的健康妇女进行甲状腺功能检测,以建立不同孕期甲状腺功能三项指标的正常参考区间。结果:TSH在早孕期(T1)[1.13(0.10-3.45)m IU/ml]有所下降,从中孕期(T2)[1.35(0.22-3.79)m IU/ml]开始逐渐回升,至晚孕期(T3)[2.18(0.68-4.96)m IU/ml]逐渐接近正常非孕人群的水平,各期水平均有明显差异(P<0.01);FT4和FT3均从早孕期就开始进行性下降,并持续整个孕程,各期水平均有明显差异(P<0.01)。结论:临床医生可根据此参考值诊断台山地区孕期甲状腺激素功能异常,早期诊断并采取有效干预措施,避免不良妊娠结局,保障母婴安全。
Objective: To investigate the reference intervals of TSH, FT4 and FT3 in normal pregnant women in Taishan during early, middle and late pregnancy. Methods: 215 cases of non-pregnancy, 210 pregnant women during pregnancy thyroid function tests to establish the normal reference interval of thyroid function in different indicators of pregnancy. Results: TSH decreased from 1.13 (0.10-3.45) mIU / ml in the first trimester of pregnancy to gradually increased from 1.35 (0.22-3.79) mIU / ml in the second trimester (T2) to late pregnancy ( T3) [2.18 (0.68-4.96) m IU / ml] gradually approached the normal non-pregnant population, with significant differences at all stages (P <0.01). Both FT4 and FT3 decreased gradually from the first trimester During the whole pregnancy, there were significant differences in the levels (P <0.01). Conclusion: According to this reference value, clinicians can diagnose thyroid hormone dysfunction during pregnancy in Taishan area, early diagnosis and take effective intervention measures to avoid adverse pregnancy outcomes and ensure the safety of mother and infant.