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目的:探讨双眼盲大鼠听、视觉通路锰增强磁共振成像(ME MRI)的形态学改变,并与病理结果相对照,验证视听跨感觉通道重组(听觉代偿通路)的产生。方法:14只健康新生雄性Sprague-Dawley(SD)大鼠随机分为双眼盲组(Group A)与正常组(Group B)(每组n=7),采用视神经离断法使大鼠致盲,盲后4个月分别经两组大鼠的左侧内耳外淋巴注入0.4M Mn Cl2,24h后比较ME MRI表现,观察是否建立听觉代偿通路,并与病理结果相对照,以帮助确定听觉代偿功能的产生。结果:ME MRI结果显示双眼盲大鼠双侧内侧膝状体、听皮质、外侧膝状体、上丘及视皮质的对比度均较正常大鼠增高,差异具有统计学意义,以听皮质较显著(P<0.01),视觉中枢差异更加明显(P<0.001)。ME MRI表现与病理结果具有较好一致性。结论:新生大鼠致盲4月后,MEMRI改变结合病理结果,提示产生视听跨感觉通道重组(听觉代偿通路)。
OBJECTIVE: To investigate the morphological changes of auditory and visual pathway manganese-enhanced magnetic resonance imaging (ME MRI) in blind rats and to verify the generation of audio-visual trans-sensory pathway remodeling (auditory compensatory pathway) in comparison with the pathological results. Methods: Fourteen healthy male Sprague-Dawley rats were randomly divided into two groups: group A (n = 7) and group B (group n = 7). The optic nerve was used to make the rats blind After 4 months of blindness, 0.4M MnCl2 was infused into the left lateral ear by two groups of rats respectively. After 24 hours, ME MRI was performed to observe whether the auditory compensatory pathway was established and compared with the pathological results to help determine the hearing Compensation function generation. Results: Compared with normal rats, ME MRI results showed that the bilateral medial geniculate bodies, auditory cortex, lateral geniculate body, superior colliculus and visual cortex of blind eyes in both eyes were higher than normal rats, the difference was statistically significant (P <0.01), and visual center difference was more obvious (P <0.001). ME MRI performance and pathological results have good consistency. CONCLUSION: After neonatal rat blinding, MEMRI changed in combination with pathological findings, suggesting the production of audiovisual trans-sensory pathway remodeling (auditory compensatory pathway).