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目的:观察急性冠脉综合征(ACS)患者血浆胸腺基质淋巴细胞生成素(TSLP)水平。方法:经冠状动脉造影证实的冠心病患者98例,其中稳定型心绞痛(SAP)组40例,ACS组58例,另选取20例造影正常者作为对照组。采用ELISA法检测血浆TSLP水平,同时常规检测患者生化指标。结果:ACS组血浆TSLP浓度[(16.5±3.0)pg/ml]显著高于SAP组[(3.3±1.4)pg/ml]和对照组[(2.8±1.3)pg/ml](均P<0.01);吸烟患者TSLP浓度[(27.9±14.6)pg/ml]显著高于非吸烟患者[(12.9±4.8)pg/ml](P<0.01)。血浆TSLP浓度与血C反应蛋白及LDL正相关(分别r=0.23,P<0.05和r=0.38,P<0.01)。结论:TSLP介导的炎症反应可能与ACS发生有关。
Objective: To observe the levels of plasma thymic stromal lymphopoietin (TSLP) in patients with acute coronary syndrome (ACS). Methods: Ninety-eight patients with coronary heart disease confirmed by coronary angiography were enrolled. Forty patients with stable angina pectoris (SAP), 58 patients with ACS, and 20 patients with normal angiography were selected as control group. Serum TSLP levels were measured by ELISA and routine biochemical tests were performed. Results: Compared with SAP group [(3.3 ± 1.4) pg / ml] and control group [(2.8 ± 1.3) pg / ml] ). The TSLP concentration in smokers was significantly higher than that in non-smokers [(27.9 ± 14.6) pg / ml] (12.9 ± 4.8 pg / ml) (P <0.01). Plasma TSLP concentrations were positively correlated with serum C-reactive protein and LDL (r = 0.23, P <0.05 and r = 0.38, respectively, P <0.01). Conclusion: TSLP-mediated inflammation may be related to the occurrence of ACS.