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目的:介绍硫普罗宁的药理作用与临床应用。方法:对近年来国内有关硫普罗宁的药理作用、药动学,临床应用,药物相互作用的文献资料加以整理、归纳。结果:硫普罗宁作为一种新型含游离巯基的甘氨酸衍生物具有保护肝细胞及促肝细胞再生,清除自由基和对重金属解毒的作用。结论:硫普罗宁可用于改善各类急慢性肝炎的肝功能,用于治疗脂肪肝、酒精肝、药物性肝损伤的治疗及重金属的解毒。
Objective: To introduce the pharmacological effects and clinical application of tiopronin. Methods: In recent years, domestic literature about the pharmacological effects of tiopronin, pharmacokinetics, clinical applications, drug interactions to be sorted out and summarized. Results: Tiopronin as a novel glycine derivative containing free thiol has the functions of protecting hepatocytes and promoting hepatocyte regeneration, scavenging free radicals and detoxifying heavy metals. Conclusion: Tiopronin can be used to improve the liver function of various acute and chronic hepatitis, and is used to treat fatty liver, alcoholic liver, drug-induced liver injury and detoxification of heavy metals.