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本题研究了抗组织胺药——异丙嗪的树脂剂,获得了作用均匀、一日只需服药一次、嗜眠副作用小的异丙嗪制剂。此外,对不同类型的国产阳离子交換树脂在制备药树脂方面的适用情况作了比较。试验采用4种粒子大小相同而交联度不同的国产阳离子交換树脂:強酸1-3、強酸1-4、強酸1-8和強酸1-12,分別制成异丙嗪药树脂。为了摸索制备异丙嗪树脂剂的条件,首先研究了上述四种离子交換树脂对异丙嗪的交換速度和交換量。试验结果表明,強酸型的阳离子交換树脂对异丙嗪的交換量都较大,每克干燥离子交換树脂(H型)可交換
This study investigated the antihistamine drug - promethazine resin agent, obtained a uniform effect, only once a day medication, narcolepsy side effects of promethazine preparation. In addition, the different types of domestic cation exchange resin in the preparation of the application of drug resin made a comparison. Test using four kinds of the same size and degree of cross-linking of different domestic cation exchange resin: strong acid 1-3, strong acid 1-4, strong acid 1-8 and strong acid 1-12, respectively, made of promethazine resin. In order to explore the conditions for the preparation of promethazine resin, the exchange rate and exchange volume of the above four ion exchange resins for promethazine were first studied. The test results show that strong acid type cation exchange resin on the promethazine exchange volume are large, per gram of dry ion exchange resin (H type) can be exchanged