目的加强临床合理用药的监督管理,规范医师用药行为,遏制大处方,降低患者药品费用、药物不良反应的发生,保证医疗质量和医疗安全。方法通过开展动员培训、自查自纠、药占比控制及强化监督考核等量化考核措施,重点针对中成药、抗菌药物、质子泵抑制剂、免疫调节剂、激素等临床应用中存在的突出问题进行专项治理。结果全院66个临床科室有54个科室药占比均有所下降,其中有14个科室降幅达5%以上;超千元处方不合格率控制在2.5%以下;不合理用药投诉率下降了4%。结论全院医务人员规范行医、合理用药的意识得到了进一步增强,药物临床应用管理得到了进一步加强,处方点评制度得到了进一步强化,医院初步建立了超常用药预警机制,保证了医疗质量和医疗安全,全院用药行为趋于更加科学、合理、安全、经济、规范。 Objective To strengthen the supervision and management of clinical rational drug use, standardize the physician’s medication behavior, curb the prescription, reduce the patient’s drug costs, adverse drug reactions and ensure the medical quality and medical safety. Methods Through quantitative evaluation measures such as mobilization training, self-examination and self-correction, drug proportion control and intensive supervision and examination, the key problems in clinical application of proprietary Chinese medicines, antimicrobial agents, proton pump inhibitors, immunomodulators and hormones are focused on Conduct special treatment. Results Among the 66 clinical departments in the hospital, 54 departments had a decline in the proportion of their medicines, of which 14 departments dropped by more than 5%; the non-compliance rate of ultra-thousand yuan prescriptions was below 2.5%; and the complaints rate of unreasonable drug use dropped 4%. CONCLUSION: The awareness of practicing medical practices and rational drug use has been further enhanced in all hospital staffs. The management of clinical application of drugs has been further strengthened and the prescription review system has been further strengthened. The hospital has initially set up an early warning mechanism for over-medication, which ensures the medical quality and medical safety , The hospital drug behavior tends to be more scientific, rational, safe, economical, standardized.