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目的探讨急性冠状动脉综合征介入术前应用他汀类药物强化治疗。方法 2009年1月至2011年1月收治的急性冠状动脉综合征患者168例,随机分为强化治疗组88例,常规治疗组80例,对两组病例于术前、术后1d、术后3d、术后7d进行血清高敏C反应蛋白检测并进行比较。结果两组术前血清高敏C反应蛋白检测比较P>0.05无显著差异性。两组术后血清高敏C反应蛋白检测比较P<0.05有显著差异性。结论在急性冠状动脉综合征介入术前应用他汀类药物强化治疗可以明显减轻介入造成炎症,稳定斑块,减少再发心肌梗死及再住院率。
Objective To investigate the use of statins for the treatment of acute coronary syndrome before intervention. Methods 168 patients with acute coronary syndrome admitted from January 2009 to January 2011 were randomly divided into intensive treatment group (n = 88) and conventional treatment group (n = 80). Two groups of patients were treated with preoperative, postoperative 1d, postoperative 3d, 7d after the serum high-sensitivity C-reactive protein detection and comparison. Results Preoperative serum high-sensitivity C-reactive protein test compared P> 0.05 no significant difference. Two groups of postoperative serum high-sensitivity C-reactive protein test compared P <0.05 significant difference. Conclusions The intensive statin treatment before PCI can obviously reduce the interventional inflammation, stabilize plaque, reduce the incidence of recurrent myocardial infarction and rehospitalization.