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目的:探讨影响2型糖尿病合并脑梗死的主要危险因素。方法:将496例住院治疗的2型糖尿病患者根据CT或MRI检查结果分为糖尿病合并脑梗死组(DMCI组)、糖尿病不伴脑梗死组(DMNCI组),并收集60例同期脑梗死无糖尿病组(CI组)作对照组,进行多因素分析。结果:DMCI组高血压患病率明显增加。DMCI组与DMNCI组比较,年龄、糖尿病病程、胰岛素水平、HOMA-IR、HOMA-IS、LDL明显增加,HDL显著降低。DMCI组与CI组比较,胰岛素水平、HOMA-IR明显增加,HOMA-IS显著降低。结论:影响2型糖尿病合并脑梗死的主要危险因素:高血压、高胰岛素血症(胰岛素抵抗)、糖尿病病程和血浆HDL水平,HDL是保护因素。
Objective: To explore the main risk factors of type 2 diabetes complicated with cerebral infarction. Methods: 496 hospitalized patients with type 2 diabetes were divided into diabetes mellitus complicated with cerebral infarction group (DMCI group) and diabetes mellitus without cerebral infarction group (DMNCI group) according to the results of CT or MRI. Sixty consecutive patients with type 2 diabetes mellitus Group (CI group) as control group, multivariate analysis. Results: The prevalence of hypertension in DMCI group increased significantly. Compared with DMNCI group, the age, diabetes course, insulin level, HOMA-IR, HOMA-IS and LDL increased significantly in DMCI group and HDL decreased significantly. Compared with CI group, the level of insulin, HOMA-IR and the HOMA-IS in DMCI group were significantly decreased. Conclusion: The main risk factors affecting type 2 diabetes mellitus complicated with cerebral infarction are hypertension, hyperinsulinemia (insulin resistance), duration of diabetes and plasma HDL levels. HDL is a protective factor.