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目的:探讨膀胱癌组织中miR-125b的表达在膀胱癌发生发展中的作用及其临床意义。方法:采用应用茎环RT-PCR的方法检测66例膀胱尿路上皮癌组织标本的miR-125b的表达,另有16例正常膀胱黏膜组织作对照,并结合临床病理资料进行统计学分析。结果:miR-125b在膀胱癌组织中的表达显著高于非肿瘤的正常膀胱黏膜组织(p<0.05),miR-125b的水平还与表达水平与膀胱癌的组织学分级、肿瘤转移、术后复发均明显相关性(P<0.05)。结论:miR-125b在膀胱癌组织中表达量升高,且与组织学分级、肿瘤转移、术后复发相关,可能作为膀胱癌诊断和预后指标。
Objective: To investigate the role of miR-125b in the development of bladder cancer and its clinical significance. Methods: The expression of miR-125b in 66 specimens of bladder urothelial carcinoma was detected by RT-PCR. Another 16 specimens of normal bladder mucosa were used as controls, and the clinical and pathological data were used for statistical analysis. Results: The expression of miR-125b in bladder cancer was significantly higher than that in non-tumorous normal bladder mucosa (p <0.05). The level of miR-125b also correlated with the histological grade of bladder cancer, tumor metastasis, Relapse were significantly correlated (P <0.05). Conclusion: The expression of miR-125b is up-regulated in bladder cancer, which is correlated with histological grade, tumor metastasis and postoperative recurrence, which may serve as a diagnostic and prognostic indicator of bladder cancer.