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目的 :通过观察实验性肝硬化形成过程中内毒素、一氧化氮 (NO )与内皮素 (ET )的动态变化 ,探讨其与肝硬化高动力循环状态的关系。方法 :采用鲎试剂基质显色法、镉还原比色法和放射免疫分析法测定了四氯化碳 (CCI4 )诱发大鼠肝硬变形成过程中血浆内毒素、NO、ET含量变化。结果 :在肝硬化进程中血浆内毒素、NO含量呈上升趋势且明显高于正常对照组 (P <0 .0 1) ,血浆ET含量呈下降趋势且明显低于正常对照组 (P <0 .0 1) ,均与肝功受损相关。结论 :血浆内毒素、NO、ET水平反映肝硬化的严重程度 ,高动力循环在肝硬化形成过程中也随之发生
Objective: To observe the dynamic changes of endotoxin, nitric oxide (NO) and endothelin (ET) in the process of experimental liver cirrhosis and to explore their relationship with hyperdynamic circulation of cirrhosis. Methods: The contents of plasma endotoxin, nitric oxide and endotoxin in plasma of rats with cirrhosis induced by carbon tetrachloride (CCI4) were determined by limulus reagent chromogenic method, cadmium reduction colorimetry and radioimmunoassay. Results: The levels of endotoxin and NO in plasma increased during the course of liver cirrhosis and were significantly higher than those in the normal control group (P <0.01). The plasma ET level showed a decreasing trend and was significantly lower than that of the normal control group (P <0. 0 1), are associated with impaired liver function. Conclusion: Plasma endotoxin, NO and ET levels reflect the severity of cirrhosis. Hyperkinetic circulation also occurs during the formation of liver cirrhosis