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目的:比较家兔静脉注射与口服左氧氟沙星后血浆和眼房水药动学。方法:选取54只家兔,分别静脉注射或口服左氧氟沙星24 mg/kg,高效液相色谱法测定血浆和眼房水药物浓度,3p97软件计算药动学参数。结果:静脉注射与口服血浆中左氧氟沙星t1/2分别为(1.42±0.29)h和(2.99±0.20)h(P<0.01);AUC(0→t)分别为(42.56±3.71)μg.h.mL-1和(33.48±2.98)μg.h.mL-1(P<0.01)。房水中左氧氟沙星t1/2分别为(2.53±0.65)h和(2.68±0.70)h;tmax分别为(0.50±0.00)h和(0.67±0.24)h(P<0.05);Cmax分别为(4.93±0.83)μg/mL和(1.59±0.38)μg/mL(P<0.01)。结论:左氧氟沙星口服给药可在血浆和房水中达较高药物浓度,但静脉注射更为明显,二者有明显差别。
Objective: To compare the pharmacokinetics of plasma and aqueous humor after intravenous and oral levofloxacin in rabbits. Methods: Fifty-four rabbits were selected for intravenous or oral administration of levofloxacin 24 mg / kg. Plasma and aqueous humor concentrations were determined by HPLC. Pharmacokinetic parameters were calculated by 3p97 software. Results: The values of levofloxacin t1 / 2 in intravenous and oral administration were (1.42 ± 0.29) h and (2.99 ± 0.20) h, respectively (P <0.01); AUC (0 → t) were (42.56 ± 3.71) μg.h respectively. mL-1 and (33.48 ± 2.98) μg.h.mL-1 (P <0.01). (2.53 ± 0.65) h and (2.68 ± 0.70) h, respectively; tmax was (0.50 ± 0.00) h and (0.67 ± 0.24) h respectively in the aqueous humor (P <0.05); Cmax was (4.93 ± 0.83) μg / mL and (1.59 ± 0.38) μg / mL (P <0.01). Conclusion: The oral administration of levofloxacin in plasma and aqueous humor can reach a higher concentration of drug, but intravenous injection is more obvious, the two have significant differences.