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目的:探讨糖尿病(DM)患者细胞内外低镁水平状态及其临床意义。方法:采用等离子直读光谱仪测定DM患者RBC Mg~(++)含量。结果:糖尿病者细胞外镁与正常对照组无明显差异(P>0.05),而细胞内Mg~(++)在血清Mg~(++)尚正常时已先期下降,其下降情况与正常对照组比较,男性DM为P<0.01,女性DM为P<0.05。结论:本组82例DM病人均存在机体Mg~(++)代谢负平衡,主要以细胞内低镁首先表现出来,此将影响细胞的各种能量代谢及核酸代谢酶活性和阳离子微环境破坏,继而使胰岛素受体活性下降。其男性DM者低镁更甚于女性DM者,提示男性DM者更易于患心血管并发症。
Objective: To investigate the intracellular and extracellular low magnesium levels in diabetic patients and its clinical significance. Methods: Plasma RBC Mg ~ (++) content was determined by plasma direct reading spectrometer. Results: There was no significant difference between the diabetic group and the normal control group (P> 0.05), while the intracellular Mg ~ (+ +) decreased preferentially when serum Mg ~ (+ +) was still normal, Group, male DM was P <0.01, female DM was P <0.05. CONCLUSIONS: All 82 patients with DM have the negative balance of Mg ~ (++) metabolism, which is mainly manifested by intracellular low magnesium, which will affect various energy metabolism and nucleic acid metabolic enzyme activities and the destruction of cationic microenvironment , Which in turn decreases insulin receptor activity. Male patients with low magnesium DM even more than female DM, suggesting that male DM more likely to suffer from cardiovascular complications.