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目的:探讨北京石景山社区非糖尿病中老年人群牙周炎各临床指标与肾小球滤过率（glomerular filtration rate，GFR）之间的相关性。方法:本研究为横断面研究，于2005年5至7月对北京石景山4个社区中老年人群（35至84岁）进行问卷调查、血生化检查、牙周指标检查，调查对象的选取采用方便抽样的方法，纳入非糖尿病、空腹血糖<6.1 mmol/L、餐后血糖<7.8 mmol/L，且口内余留牙≥10颗者，排除糖尿病、空腹血糖≥6.1 mmol/L或餐后血糖≥7.8 mmol/L、全口余留牙小于10颗以及项目和资料收集不完整者，共有362名研究对象符合纳入条件。检查受检者的全口平均探诊深度（periodontal depth，PD）、出血指数（bleeding index，BI）、附着丧失（attachment loss，AL）和菌斑指数（plaque index，PLI），以及PD≥4 mm%（全口PD≥4 mm的位点数占全口位点总数的百分比，其他%指标同理）、PD≥5 mm%、PD≥6 mm%、AL≥3 mm%、AL≥4 mm%、AL≥5 mm%、AL≥6 mm%等指标，以血清肌酐值计算GFR水平，GFR≥90 ml/（min·1.73 mn 2）被定义为GFR正常组，GFR<90 ml/（min·1.73 mn 2）被定义为GFR降低组，组间进行单因素分析，和以GFR为因变量并校正年龄、性别、是否吸烟、腰臀比、体育锻炼等危险因素的多因素回归分析。n 结果:362名研究对象中，GFR正常组164人（45.3%），GFR降低组198人（54.7%）。GFR降低组的男性占比［59.6%（118/198）］显著高于GFR正常组［44.5%（73/164）］（n P=0.004）；GFR降低组年龄、尿酸、三酰甘油、腰臀比的中位数（分别为65岁、323 mmol/L、1.73 mmol/L、0.90）均显著高于GFR正常组（分别为54岁、277 mmol/L、1.45 mmol/L、0.88）（n P<0.05）；GFR降低组的PD均值、AL均值、BI均值、PD≥4 mm%、AL≥3 mm%、AL≥4 mm%的中位数分别为2.80 mm、2.52 mm、2.06、20.4%、46.5%、30.4%，均显著高于GFR正常组（分别为2.60 mm、2.37 mm、1.93、16.6%、42.9%、28.9%）（n P<0.05）；Logistic回归分析调整年龄、性别、是否吸烟、腰臀比、体育锻炼等混杂因素后，结果显示牙周指标中的PD均值、AL均值、PD≥4 mm%、PD≥5 mm%、PD≥6 mm%、AL≥3 mm%、AL≥4 mm%等指标与该人群GFR降低具有显著相关性，n OR值分别为1.765、1.879、1.430、1.713、1.771、1.428及1.445（n P<0.05）。n 结论:在北京石景山社区非糖尿病中老年人群中，反映牙周组织破坏程度的临床指标与GFR降低具有相关性。“,”Objective:To investigate the correlation between clinical periodontal indexes of periodontitis and glomerular filtration rate (GFR) in a non-diabetic elderly population in four communities of Shijingshan, Beijing.Methods:This was a cross-sectional study. Questionnaires, blood biochemical examinations, and periodontal indexes were conducted in elderly people (35 to 84 years old) in four communities of Shijingshan, Beijing between May and July 2005. Non-diabetic patients with fasting blood glucose<6.1 mmol/L, postprandial blood glucose<7.8 mmol/L, and ≥ 10 remaining teeth were included. Patients with diabetes, fasting blood glucose ≥6.1 mmol/L or postprandial blood glucose ≥7.8 mmol/L, and total residual teeth less than 10 were excluded. A total of 362 study subjects met the inclusion criteria. The survey subjects were selected by convenient sampling method. The mean full-mouth probing depth (PD), bleeding index (BI), attachment loss (AL), and plaque index (PLI), as well as PD≥4 mm% (the number of sites with PD≥4 mm as a percentage of the total number of sites in full mouth), PD≥5 mm%, PD≥6 mm%, AL≥3 mm%, AL≥4 mm%, AL≥5 mm% and AL≥6 mm% were used for the analysis. Serum creatinine values was used to calculate GFR. GFR≥90 ml/(min·1.73 mn 2) was defined as normal group and GFR<90 ml/(min·1.73 mn 2) was defined as reduced group. Univariate analysis was conducted between two groups. Multivariate regression analysis was performed with GFR as dependent variable and adjusted for risk factors such as age, sex, smoking, waist-hip ratio and physical activity.n Results:There were 164 subjects in the normal GFR group (45.3%) and 198 in the reduced GFR group (54.7%). Percentage of males in the reduced GFR group, 118 in total, accounting for 59.6%, were significantly higher than in the normal GFR group (73, 44.5%)(n P=0.004). The median of age, uric acid, triglyceride, and waist-to-hip ratio (65 years, 323 mmol/L, 1.73 mmol/L, 0.90) were significantly higher in the reduced GFR group than in the normal GFR group (54 years, 277 mmol/L, 1.45 mmol/L, 0.88) (n P<0.05). The median of PD mean, AL mean, BI mean, PD≥4 mm%, AL≥3 mm%, and AL≥4 mm% in the reduced GFR group were 2.80 mm, 2.52 mm, 2.06, 20.4%, 46.5%, and 30.4%, respectively, which were significantly higher than those in the GFR normal group (2.60 mm, 2.37 mm, 1.93, 16.6%, 42.9%, 28.9%) (n P<0.05). After adjusting for confounding factors such as age, gender, smoking, waist-to-hip ratio and physical activity, the results of logistic regression analysis showed that PD mean, AL mean, PD≥4 mm%, PD≥5 mm%, PD≥6 mm%, AL≥3 mm% and AL≥4 mm% of clinical periodontal indexes were significantly correlated with reduced GFR in this population (n OR values were 1.765, 1.879, 1.430, 1.713, 1.771, 1.428, 1.445, respectively, n P<0.05).n Conclusions:In the non-diabetic elderly population in communities of Shijingshan, Beijing, clinical periodontal indexes reflecting the degree of periodontal tissue destruction were associated with a decreased level of GFR.