造血干 祖细胞 (HSC)的迁移、归巢以及在骨髓造血微环境的定位对保持造血稳定具有重要意义。骨髓造血微环境由多种细胞组成 ,并表达多种粘附分子及配体 ,分泌多种细胞因子 ,在维持HSC的自我更新、增殖和分化过程中发挥重要的生理功能 The migration and homing of hematopoietic stem and progenitor cells (HSC) and their localization in the hematopoietic microenvironment of bone marrow are of great significance for the maintenance of hematopoietic stability. The hematopoietic microenvironment of the bone marrow consists of a variety of cells and expresses a variety of adhesion molecules and ligands that secrete a variety of cytokines that play an important physiological role in maintaining HSC self-renewal, proliferation and differentiation