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目的观察氟康唑、伊曲康唑、特比萘芬治疗系统性普通裂褶菌感染的疗效。方法建立小鼠系统性普通裂褶菌感染模型,观察给药后小鼠的生存率、中位生存时间、组织逆培养阳性率、肝脏组织载菌量。结果氟康唑组、伊曲康唑组、特比萘芬组、生理盐水对照组小鼠21d观察期内生存率分别为64.00%,68.00%,20.00%,12.00%;中位生存时间分别为>21d,>21d,11d和8d;肝脏组织逆培养阳性率分别为60.00%,68.00%,100.00%,100.00%;肝脏组织载菌量分别为19.533±4.121,20.706±5.193,32.920±8.485,36.520±9.138。结论氟康唑和伊曲康唑在小鼠体内均有较好的抗普通裂褶菌活性,而特比萘芬效果较差,氟康唑与伊曲康唑之间无疗效差别。
Objective To observe the efficacy of fluconazole, itraconazole and terbinafine in the treatment of systemic common schizophrenia. Methods The systemic schizophrenia model was established in mice. The survival rate, median survival time, the positive rate of reverse culture and the amount of bacteria in liver tissue were observed after administration. Results The survival rates of fluconazole group, itraconazole group, terbinafine group and saline control group for 21 days were 64.00%, 68.00%, 20.00% and 12.00%, respectively. The median survival time was > 21d,> 21d, 11d and 8d respectively. The positive rates of reverse culture in liver tissue were 60.00%, 68.00%, 100.00% and 100.00%, respectively. The contents of liver bacteria were 19.533 ± 4.121,20.706 ± 5.193,32.920 ± 8.485,36.520 ± 9.138. Conclusion Both fluconazole and itraconazole have good antifungal activity against Schizophyllum commune in mice, whereas terbinafine is less effective. There is no difference in efficacy between fluconazole and itraconazole.