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目的研究免疫抑制剂在急性间质性肾炎中的应用疗效。方法选取广州市番禺区中心医院在2013年1月至2014年1月间收治的72例急性间质性肾炎患者的临床资料,根据数字随机分组法原则将患者分为两组,每组各36例。对照组为常规针对性治疗,观察组在常规治疗基础上采用免疫抑制剂治疗,比较两组患者的治疗效果与治疗前后指标血肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白定量、尿β2微球蛋白(β2-MG)的变化情况。结果观察组中有44例患者治疗有效,总有效率为94.44%;对照组中有28例患者治疗有效,总有效率为77.78%,治疗有效率比较差异有统计学意义(P<0.05)。治疗后,观察组生化指标改善情况优于对照组,差异有统计学意义(P<0.05)。结论免疫抑制剂在急性间质性肾炎疾病的治疗中可被应用,有利于取得较好的治疗效果,改善患者相关指标的变化情况,值得临床推广应用。
Objective To study the effect of immunosuppressive agents in acute interstitial nephritis. Methods The clinical data of 72 patients with acute interstitial nephritis admitted in Central Hospital of Panyu District of Guangzhou from January 2013 to January 2014 were divided into two groups according to the principle of digital randomization example. The control group was routinely targeted treatment. The observation group was treated with immunosuppressive drugs on the basis of conventional treatment. The therapeutic effect of the two groups were compared with those before and after treatment. Serum creatinine (Scr), blood urea nitrogen (BUN), 24 h urinary protein , Urine β2 microglobulin (β2-MG) changes. Results In the observation group, 44 patients were effective and the total effective rate was 94.44%. In the control group, 28 patients were treated effectively and the total effective rate was 77.78%. The effective rate of treatment was statistically significant (P <0.05). After treatment, the improvement of biochemical indexes in the observation group was better than that in the control group, with significant difference (P <0.05). Conclusions Immunosuppressive agents can be used in the treatment of acute interstitial nephritis diseases, which is good for obtaining better therapeutic effects and improving the changes of relevant indicators in patients. It is worthy of clinical application.