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目的了解合肥市药品不良反应(ADR)发生特点及引发的相关因素,促进安全、合理用药。方法合肥市2006年1月1日~2006年12月31日共收集到ADR病例报告1549份,用Excel电子表和手工方法进行分析评价。结果1549份ADR病例报告中,涉及到药品1680例。主要不良反应累及系统—器官及其临床表现为胃肠系统损害。涉及国家药品不良反应通报品种18种。结论应合理使用抗微生物药物及中药注射剂,注意口服给药指征,慎重选用静脉滴注给药治疗,加强对中药注射剂和国家通报品种的监测,确保安全合理用药。
Objective To understand the characteristics of ADR and its related factors in Hefei and promote safe and rational drug use. Methods A total of 1549 cases of ADR cases were collected from January 1, 2006 to December 31, 2006 in Hefei City. The data were analyzed and evaluated by Excel spreadsheet and manual method. Results 1549 ADR cases reported 1680 cases of drugs. The major adverse effects involve the systemic-organ and its clinical manifestations of gastrointestinal damage. Eighteen species were reported involving national adverse drug reactions. Conclusion The antimicrobial drugs and Chinese medicine injection should be used rationally. Indications for oral administration should be paid attention. Intravenous infusion should be used carefully to improve the monitoring of traditional Chinese medicine injections and national notified varieties to ensure safe and rational drug use.