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目的观察不同剂量γ-氨基丁酸(GABA)对急性毒鼠强(TET)中毒小鼠的治疗作用,为其用于临床治疗提供实验基础。方法通过小鼠急性毒性实验观察染毒即刻以及染毒10 min 后分别给予低剂量和大剂量 GABA 行解毒治疗,并观察各组小鼠脑组织细胞的病理学改变。结果 GABA 能有效缓解急性毒鼠强中毒小鼠症状,减轻惊厥发作,延缓抽搐出现,降低中毒小鼠的病死率。中毒后即刻用药治疗比10 min 后用药治疗效果较好。在小鼠对 GABA 治疗最大耐受量范围内,即刻大剂量 GABA 治疗比小剂量 GABA 治疗急性毒鼠强中毒疗效好。结论 GABA 对急性毒鼠强中毒小鼠有明显治疗作用,提示 GABA 有望成为临床上救治急性毒鼠强中毒的优良解毒剂,但在 GABA 对毒鼠强解毒的具体的量效关系方面尚需进一步探讨。
Objective To observe the therapeutic effects of different doses of γ-aminobutyric acid (GABA) on mice with acute tetramine poisoning (TET) and provide the experimental basis for its clinical treatment. Methods Acute toxicity test in mice was performed immediately and exposed to low and high doses of GABA for 10 minutes after exposure. The pathological changes of brain cells in each group were observed. Results GABA can effectively alleviate the symptoms of acute tetramine poisoning mice, reduce seizures, delay the appearance of convulsions and reduce the mortality of poisoned mice. Immediate poisoning after treatment than 10 min after treatment is better. Within the maximum tolerated dose of GABA in mice, immediate high-dose GABA treatment is more effective than low-dose GABA in the treatment of acute tetramine poisoning. Conclusions GABA has a significant therapeutic effect on mice with acute tetramine poisoning, suggesting that GABA may be an excellent antidote for the acute treatment of acute tetramine poisoning. However, the specific dose-response relationship between GABA and tetanus toxoid Discussion.