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目的探讨并比较肾炎康复片与坎地沙坦酯治疗糖尿病肾病临床效果。方法选取本院肾内科2010年2月～2012年7月收治糖尿病肾病患者150例,采用随机数字表法分为对照组和观察组,每组各75例;其中对照组患者采用坎地沙坦酯口服治疗;观察组患者则采用肾炎康复片口服治疗;比较两组患者临床治疗总有效率、治疗前后UAER及其他生化指标等。结果对照组和观察组患者临床治疗总有效率分别为78.7%,92.0%;观察组患者临床治疗总有效率明显高于对照组,组间比较差异显著(P<0.05);对照组与观察组患者治疗前UAER、BUN及Cr等生化指标组间比较差异无统计学意义(P>0.05);两组患者治疗后UAER、BUN及Cr等生化指标较治疗前均明显下降,且观察组患者治疗后UAER、BUN及Cr等生化指标下降程度明显优于对照组,组间比较差异具有统计学意义(P<0.05)。结论相较于坎地沙坦酯,肾炎康复片治疗糖尿病肾病可有效改善患者临床症状,恢复肾功能,具有临床推广使用价值。
Objective To investigate and compare the clinical effects of nephritis kangshen tablets and candesartan cilexetil on diabetic nephropathy. Methods 150 patients with diabetic nephropathy were enrolled in our hospital from February 2010 to July 2012. The patients were divided into control group and observation group with 75 cases in each group by random number table. The patients in control group were treated with candesartan Ester oral treatment; observation group patients were treated with nephritis rehabilitation tablets oral treatment; compared the total effective rate of clinical treatment in both groups, before and after treatment UAER and other biochemical indicators. Results The total effective rate of clinical treatment in control group and observation group was 78.7% and 92.0% respectively. The total effective rate of clinical treatment in observation group was significantly higher than that in control group, with significant difference (P <0.05) between control group and observation group There was no significant difference in the biochemical indexes such as UAER, BUN and Cr between the two groups before treatment (P> 0.05). The biochemical indexes such as UAER, BUN and Cr in the two groups were significantly lower than those before treatment, and the treatment group The biochemical indexes such as UAER, BUN and Cr were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). Conclusion Compared with candesartan cilexetil and nephritis kangfu tablet in the treatment of diabetic nephropathy, the clinical symptoms and the recovery of renal function can be effectively improved, which has the value of clinical popularization and use.