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目的:探讨细菌感染引起胆囊基底膜IgG型免疫复合物沉积导致胆囊结石形成的影响。方法:手术摘除结石中细菌培养及IC(免疫复合物)组化染色,术后胆囊组织切片IC组化染色,术前、术后5d测定CIC(循环免疫复合物)、Ig(免疫球蛋白)。结果:胆石中IC阳性率为82%(41/50),细菌培养阳性率为80%(40/50),主要是大肠杆菌。胆囊组织切片中IC阳性率为90%(87/97)。与对照组比较,胆结石患者术前血中CIC(5·3±1·5)u/L,vs(1·2±0·8)u/L,(P<0·01)增高,IgG(8·7±2·0)g/Lvs(11·2±3·2)g/L,(P<0·05)降低,术后恢复正常。结论:细菌感染引起胆囊基底膜IgG型免疫复合物沉积与胆结石形成有关。
Objective: To investigate the bacterial infection caused by gallbladder basement membrane IgG immune complexes lead to gallstone formation. Methods: Bacterial culture and IC (immunocomplex) staining were performed in the stone removed by surgery. The ICG staining of gallbladder tissue sections was performed. The levels of CIC (circulating immune complex), Ig (immunoglobulin) . Results: The positive rate of IC in gallstone was 82% (41/50), and the positive rate of bacterial culture was 80% (40/50), mainly E. coli. The positive rate of IC in gallbladder tissue was 90% (87/97). Compared with the control group, CIC (5.3 ± 1.5) u / L, vs (1.2 ± 0.8) u / L, (P <0.01) (8.7 ± 2.0) g / L vs (11 · 2 ± 3.2) g / L, (P <0.05), and returned to normal after operation. Conclusion: The bacterial infection causes the gallbladder basement membrane IgG immunocomplex deposition and gallstone formation.