气道内前列腺素和缓激肽浓度增高,对应用血管紧张素转换酶抑制剂的咳嗽患者来说,有时发现是咳嗽敏感性增高的可能原因。为此,本文的咳嗽患者对PGE_2、缓激肽(BK)、组胺(H)和枸椽酸(C)在辣椒素引起咳嗽和呼吸道阻力增高中的作用进行了观察。方法正常受检者6人,男4,女2例,平均年龄36岁,近期均无呼吸道感染或咳嗽病史。随机吸入生 Increased concentrations of prostaglandins and bradykinin in the airways are sometimes found to be responsible for increased cough sensitivity in cough patients using angiotensin converting enzyme inhibitors. For this reason, the role of PGE 2, bradykinin (BK), histamine (H), and citric acid (C) in cough and cough caused by capsaicin and increased airway resistance was observed in this study. Methods Normal subjects were 6, 4 males and 2 females, mean age 36 years old, no recent history of respiratory tract infection or cough. Randomly inhaled