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目的探讨T2DM患者血浆N末端B型脑钠肽(NT-proBNP)水平及相关的影响因素。方法选取T2DM患者81例及健康人30名(NC),按HbA_1c水平将T2DM患者分为HbA_1c<9.0%组51例、HbA_1c≥9.0%组30例,检测各组NT-proBNP水平及相关生化指标。结果与NC组比较,HbA_1c<9.0%组及HbA_1c≥9.0%组NT-proBNP水平及胰岛β细胞功能指数(HOMA-β)降低,HbA_1C≥9.0%组更低[(2.01±0.56)vs(1.83±0.23)vs(1.65±0.24)pg/ml,(3.91±0.18)vs(3.72±0.29)vs(3.41±0.30),P<0.01]。与NC组比较,HbA_1c<9.0%组及HbA_1c≥9.0%组FPG增高,HbA_1c≥9.0%组更高[(5.17±0.96)vs(6.82±1.93)vs(9.17±2.69)mmol/L,P<0.01]。Pearson相关分析显示,NT-proBNP与FPG、HbA_1c、BMI、HOMA-IR呈负相关,(r=-0.281、-0.279、-0.332、-0.233,P<0.05),与HOMA-β无相关性(r=0.17,P>0.05)。多元线性回归分析显示,年龄、BMI、HbA_1c是NT-proBNP的影响因素(P<0.05)。结论 NT-proBNP可能参与血糖的调节,糖尿病患者NT-proBNP水平下降,并与血糖控制水平呈负相关,且受年龄、BMI影响,NT-proBNP增高是糖尿病的保护因素。
Objective To investigate the plasma level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in T2DM patients and the related factors. Methods Twenty-one T2DM patients and 30 healthy subjects (NC) were selected. According to the HbA_1c level, 51 patients with T2DM were divided into HbA_1c group (9.0%) and HbA_1c (9.0%) group. Thirty NT-proBNP levels and related biochemical parameters . Results Compared with NC group, NT-proBNP and HOMA-β decreased in HbA 1c group <9.0% and HbA 1c≥9.0% group compared with NC group (2.01 ± 0.56 vs 1.83 ± 0.23 vs 1.65 ± 0.24 pg / ml, 3.91 ± 0.18 vs 3.72 ± 0.29 vs 3.41 ± 0.30, P <0.01, respectively. Compared with NC group, FPG in HbA_1c group and HbA_1c≥9.0% group were higher than those in HbA_1c group (9.07 ± 0.96 vs 6.82 ± 1.93 vs 9.17 ± 2.69 mmol / L, P < 0.01]. Pearson correlation analysis showed that NT-proBNP was negatively correlated with FPG, HbA 1c, BMI and HOMA-IR (r = -0.281, -0.279, -0.332, -0.233, P < r = 0.17, P> 0.05). Multivariate linear regression analysis showed that age, BMI and HbA_1c were the influencing factors of NT-proBNP (P <0.05). Conclusion NT-proBNP may be involved in the regulation of blood glucose, NT-proBNP level in diabetic patients is decreased, and is negatively correlated with the level of blood glucose control. Influenced by age and BMI, increased NT-proBNP is a protective factor of diabetes.