The novel drug delivery systems have been attracted by more and more pharmaceutical companies because of their bright future,great potential,and increasing marketing share for pharmaceutical products.However,the industrialization for novel drug delivery systems,for example nanoparticles,microspheres,and microneedles,have some limitations due to lack of bridge connecting laboratory study and industrialization.In this presentation,the difficulties of some drug delivery systems such as long-acting injection,nanoparticle based pulmonary delivery system,tableting pellet,and microneedle transdermal delivery systems,will be discussed.Some considerations for enhancing the industrialization,including pharmaceutical process and engineering,formulation strategy,excipients selection,and interdisciplinary skills,will be suggested.