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目的 探讨脑白质疏松症患者载脂蛋白 E基因多态性与血脂水平的关系。方法 采用聚合酶链反应—限制片段长度多态性对 50例脑白质疏松症患者和 1 0 8例正常对照者载脂蛋白 E基因型进行分析并进行血脂水平测定。结果 脑白质疏松症患者 Apo E2等位基因频率为 0 .1 5,明显高于对照组的 0 .0 74(P<0 .0 5) ;含 Apo E2等位基因患者的甘油三酯、低密度脂蛋白 ;载脂蛋白 B的含量均高于 Apo E3等位基因患者。结论 载脂蛋白 E2等位基因可能是脑白质疏松症的一种遗传易感因子 ,Apo E基因多态性可能通过影响血脂水平而影响脑白质疏松症的发生。
Objective To investigate the relationship between apolipoprotein E gene polymorphism and serum lipids in patients with leukoaraiosis. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the apolipoprotein E genotypes in 50 patients with leukoaraiosis and 108 normal controls and the blood lipid levels were determined. Results The frequency of allele Apo E2 in patients with leukoaraiosis was 0.15, which was significantly higher than that in control subjects (P <0.05). The triglycerides in patients with Apo E2 allele were lower Density lipoprotein; apolipoprotein B levels were higher than Apo E3 allele patients. Conclusion The apolipoprotein E2 allele may be a predisposing factor for leukoaraiosis. Polymorphism of Apo E gene may affect the development of leukoaraiosis by affecting blood lipid levels.