p53肿瘤抑制基因突变与多数恶性肿瘤的发生发展有关,包括肝细胞癌(hepatocelluar carcinoma,HCC)在内的人类恶性肿瘤中至少有50%发生了p53基因改变。因此,以正常p53基因治疗肿瘤就成了研究热点,随着介入放射学(inter-ventional radiology)向纵深发展,经介入放射方法进行肝癌的基因治疗令人关注。本文介绍了p53基因的结构与功能,其与肝癌的病理联系以及在肝癌治疗中的应用。 The mutation of p53 tumor suppressor gene is associated with the development of most malignant tumors. At least 50% of human malignancies, including hepatocelluar carcinoma (HCC), undergo p53 gene mutation. Therefore, the treatment of tumors with normal p53 gene has become a research hotspot. With the development of inter -ventional radiology, the gene therapy of liver cancer by interventional radiotherapy is of concern. This article describes the structure and function of p53 gene, its pathological relationship with liver cancer and its application in the treatment of liver cancer.