论文部分内容阅读
目的:观察槐杞黄颗粒预防支气管哮喘儿童呼吸道感染的临床疗效。方法:将72例支气管哮喘患儿随机分成治疗组和对照组,每组36例。两组患儿均给予沙美特罗替卡松雾化吸入及孟鲁司特钠口服,治疗组在此基础上给予槐杞黄颗粒口服,治疗周期为3个月。观察并比较两组患儿的感染发生情况、免疫功能、肺功能,采用中文版儿童哮喘控制测试问卷(Ch-CACT)对两组患儿进行评估。结果:整个研究期间,治疗组的感染率为21.9%,对照组为34.3%,两组比较差异有统计学意义(P<0.05)。治疗后及随访3个月时,治疗组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD4+/CD8+较治疗前均显著升高(P<0.05),IgE水平显著降低(P<0.05);随访3个月时,对照组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD8+、CD4+/CD8+亦显著升高(P<0.05),IgE水平显著降低(P<0.05);且治疗后及随访3个月时,治疗组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD4+/CD8+较对照组亦显著升高(P<0.05)。治疗后及随访3个月时,两组患儿的FEV1、PEF、Ch-CACT评分较治疗前均显著升高(P<0.05)。结论:槐杞黄颗粒能明显改善支气管哮喘儿童的免疫功能,降低其感染及哮喘发作的次数,对支气管哮喘儿童反复呼吸道感染具有较好的预防作用。
Objective: To observe the clinical efficacy of Huaiqi Huang granules in preventing respiratory infection in children with bronchial asthma. Methods: 72 cases of children with bronchial asthma were randomly divided into treatment group and control group, 36 cases in each group. Both groups were given Salmeterol and Tacrolimus inhalation inhalation and oral montelukast sodium, the treatment group on the basis of Huai Qi Huang granules given orally, the treatment period of 3 months. The incidence of infection, immune function and pulmonary function were observed and compared between two groups. Ch-CACT was used to evaluate the two groups of children. Results: The infection rate of the treatment group was 21.9% and that of the control group was 34.3% throughout the study period. The difference between the two groups was statistically significant (P <0.05). The levels of IgA, IgG, IgM and the levels of CD3 +, CD4 +, CD4 + / CD8 + in treatment group were significantly higher than those before treatment (P <0.05) and IgE levels were significantly decreased (P <0.05) ; IgA, IgG, IgM and CD3 +, CD4 +, CD8 +, CD4 + / CD8 + were also significantly increased (P <0.05) and IgE levels were significantly decreased in the control group (P <0.05) The levels of IgA, IgG and IgM and the levels of CD3 +, CD4 +, CD4 + / CD8 + in the treatment group were significantly higher than those in the control group at 3 months after follow-up (P <0.05). After treatment and at 3 months of follow-up, the FEV1, PEF and Ch-CACT scores in both groups were significantly higher than those before treatment (P <0.05). Conclusion: Huai Qi Huang granules can significantly improve the immune function of children with bronchial asthma, reduce the number of infections and asthma attacks, and have a good preventive effect on recurrent respiratory tract infections in children with bronchial asthma.