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目的探讨三阴性乳腺癌(TNBC)的超声造影特征。方法回顾性分析126例经病理证实的乳腺癌患者,根据术后免疫组织化学结果,将其分为TNBC组(n=25)和非TNBC组(n=101),比较两组的超声造影特征。结果 TNBC组造影后多表现为高增强,形态规则,边界清,内部有充盈缺损,可见穿支血管,血管形态多为分支型,与非TNBC组相比差异有统计学意义(P<0.05)。另外,TNBC组造影前后病灶大小差值较非TNBC组小(P<0.05)。而两组造影后的造影剂分布特点、增强方向、周边有无血管影、周边有无放射状汇聚、灌注曲线形态等特征均无明显统计学差异(P>0.05)。结论 TNBC具有一定的超声造影特征,超声造影可为早期预测性诊断TNBC提供更多的影像学信息。
Objective To investigate the contrast-enhanced ultrasound features of triple negative breast cancer (TNBC). Methods A total of 126 patients with pathologically confirmed breast cancer were retrospectively analyzed. According to the postoperative immunohistochemical results, they were divided into TNBC group (n = 25) and non-TNBC group (n = 101) . Results The TNBC group showed high enhancement after operation. The morphology of the TNBC group was clear with clear boundary and filled defect. The perforating branches and vessels were mostly branched. Compared with the non-TNBC group, the difference was statistically significant (P <0.05) . In addition, TNBC group before and after contrast lesion size smaller than non-TNBC group (P <0.05). There was no significant difference between the two groups in the distribution of contrast media after contrast enhancement, direction of enhancement, peripheral blood vessel shadow, peripheral radial convergence, perfusion curve morphology and other characteristics (P> 0.05). Conclusions TNBC has some characteristics of contrast-enhanced ultrasound. Contrast-enhanced ultrasound can provide more radiographic information for early predictive diagnosis of TNBC.