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目的探讨慢性充血性心力衰竭(CHF)患者血清基质金属蛋白酶(MMPs)的变化。方法CHF患者15例,正常对照组15例,采用Luminex液相芯片分析平台测定血清MMP-3及MMP-9的含量。结果CHF患者血清MMP-3,MMP-9的含量比正常对照组明显增加(P<0.05)。结论CHF患者血清MMP-3,MMP-9含量增高,与心室重构有关。
Objective To investigate the changes of serum matrix metalloproteinases (MMPs) in patients with chronic congestive heart failure (CHF). Methods Fifteen CHF patients and 15 normal controls were enrolled in this study. The serum levels of MMP-3 and MMP-9 were measured by Luminex liquid chromatography. Results The serum levels of MMP-3 and MMP-9 in CHF patients were significantly higher than those in normal controls (P <0.05). Conclusions Serum levels of MMP-3 and MMP-9 in CHF patients are increased, which are related to ventricular remodeling.