目的探究在妇科恶性肿瘤患者中,宫颈癌和卵巢癌与梅毒螺旋体感染的相关性。方法选取2013年2月-2016年8月医院妇科住院治疗的宫颈癌患者269例和卵巢癌患者106例为研究对象,并选取1 000例普通患者作为对照,对宫颈癌组、卵巢癌组和普通患者组进行梅毒螺旋体感染检查,比较三组患者梅毒螺旋体感染率,对宫颈癌和卵巢癌患者按照术后病理学诊断进行分型,比较各主要类型患者的梅毒螺旋体感染率;比较宫颈癌组患者不同分期、不同年龄段、不同学历区间的梅毒螺旋体感染率。结果宫颈癌组患者感染梅毒螺旋体31例,感染率为11.5%,卵巢癌组患者感染梅毒螺旋体4例,感染率为3.8%,普通患者组感染梅毒螺旋体34例,感染率为3.4%,宫颈癌组与普通患者组梅毒螺旋体感染率比较差异有统计学意义(P<0.05),而卵巢癌组与普通患者组梅毒螺旋体感染率比较差异无统计学意义;宫颈鳞状细胞癌患者感染率为12.6%,宫颈腺癌患者感染率为3.2%,腺鳞癌患者感染率为0,宫颈鳞状细胞癌患者梅毒螺旋体感染率与其他宫颈癌病理分型比较,差异有统计学意义(P<0.05),浆液性囊腺癌患者感染率为4.1%,黏液性囊腺癌患者感染率为2.8%,子宫内膜样癌患者感染率为4.8%,卵巢癌3种病理分型患者梅毒螺旋体感染率比较差异无统计学意义;宫颈癌Ⅰ期患者感染率为16.2%,宫颈癌Ⅱ期患者感染率为6.3%,宫颈癌组不同分期感染率比较,差异有统计学意义(P<0.05);30~39岁区间梅毒螺旋体感染率为18.5%,40~49岁区间感染率为24.6%,50~59岁区间感染率为5.6%,>60岁区间感染率为2.0%,宫颈癌组不同年龄区间的感染率比较,差异有统计学意义(P<0.05);高中学历以下患者感染率为16.2%,高中学历及以上患者感染率为5.8%,宫颈癌组不同学历区间的感染率比较,差异有统计学意义(P<0.05)。结论宫颈癌患者有更大可能性感染梅毒螺旋体,卵巢癌患者与感染梅毒螺旋体无明显关系,且宫颈癌患者感染梅毒螺旋体与病理分型、病理分期、年龄和学历有关。 Objective To investigate the correlation between cervical and ovarian cancer and Treponema pallidum infection in gynecological malignancies. Methods From February 2013 to August 2016, 269 cases of cervical cancer and 106 cases of ovarian cancer hospitalized by gynecological hospital were enrolled in this study. A total of 1 000 cases of common patients were selected as the control group. Cervical cancer group, ovarian cancer group and Treponema pallidum infection was detected in the general patient group, and the infection rate of Treponema pallidum was compared among the three groups. According to the postoperative pathological diagnosis, the infection rates of Treponema pallidum were compared between cervical cancer and ovarian cancer patients. Treponema pallidum infection rates in patients with different stages, different age groups, different academic qualifications. Results In the cervical cancer group, 31 cases were infected with Treponema pallidum, the infection rate was 11.5%. In the ovarian cancer group, 4 cases were infected with Treponema pallidum, the infection rate was 3.8%. In the common group, 34 cases were infected with Treponema pallidum, the infection rate was 3.4% The infection rate of Treponema pallidum among groups was significantly different from that of common patients (P <0.05), while the infection rate of Treponema pallidum between ovarian cancer group and common patients was no significant difference. The infection rate of cervical squamous cell carcinoma was 12.6 %, The infection rate of cervical adenocarcinoma was 3.2%, the infection rate of adenosquamous carcinoma was 0, the infection rate of Treponema pallidum among patients with cervical squamous cell carcinoma was significantly different from that of other cervical cancer (P <0.05) , The infection rate of serous cystadenocarcinoma was 4.1%, the infection rate of mucinous cystadenocarcinoma was 2.8%, the infection rate of endometrioid carcinoma was 4.8%, the infection rate of treponema pallidum among the three pathological types of ovarian cancer There was no significant difference between the two groups (P <0.05). The infection rate of stage Ⅰ cervical cancer patients was 16.2%, that of stage Ⅱ cervical cancer patients was 6.3%, and that of cervical cancer stage was statistically significant (P0.05) 39-year interval syphilis infection rate was 18.5%. The infection rate in the range of 40-49 years old was 24.6%, that in the range of 50-59 years old was 5.6%, and that in the region of> 60 years old was 2.0%. The infection rates in different age groups of cervical cancer group were statistically different (P <0.05). The infection rate of patients with high school education was 16.2%, and the infection rate of high school education and above was 5.8%. The infection rates of cervical cancer patients with different academic records were significantly different (P <0.05). Conclusion There is a higher possibility of cervical cancer patients infected with Treponema Pallor, ovarian cancer patients infected with Treponema pallidum and no significant relationship, and cervical cancer patients infected with Treponema pallidum and pathological type, pathological stage, age and academic qualifications.