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大电导钙激活钾通道(BKCa)由形成孔道的α亚基及具有调节作用的β亚基组成,因其电导大,对调节平滑肌细胞功能起重要作用,从而成为近年来研究的热点。研究发现雌激素经细胞膜上的雌激素受体介导,通过胞内多种信号转导通路激活内皮型一氧化氮合酶进而产生NO直接或间接激活BKCa通道,产生快速血管效应。随着分子生物学及膜片钳技术的发展,人们在雌激素对BKCa调节机制方面进行了深入的研究,本文就此内容进行综述。
Large-conductance calcium-activated potassium channel (BKCa) is composed of pore-forming α-subunit and regulatory β-subunit, which plays an important role in the regulation of smooth muscle cell function due to its large conductance. It has become a hot spot in recent years. The study found that estrogen is mediated by the estrogen receptor on the cell membrane and activates endothelial nitric oxide synthase through various intracellular signaling pathways to produce NO directly or indirectly activating BKCa channels to produce rapid vascular effects. With the development of molecular biology and patch-clamp technology, the research on the regulation mechanism of BKCa by estrogen has been deeply studied in this paper.