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目的:探讨奥扎格雷纳注射液对早期糖尿瘸肾瘸尿蛋白及高凝状态的影响。方法:选择在我院肾内科住院的早期糖尿病肾病的患者110人,随机分为观察组(56例)和对照维(54例),观察组用奥扎格雷纳250ml静脉滴注,每日1次;对照组仅给予常规的治疗,15d为1个疗程。治疗前后分别检测血糖、出凝血时间、纤维蛋白原、血小板等临床指标,比较两组的治疗效果。结果:观察组患者尿蛋白减少有统计学意义(P<0.05),出凝血时间、纤维蛋白原等改变存在统计学意义(P<0.05)。结论:奥扎格雷纳注射液对早期糖尿病肾病具有减少尿蛋白、改善高凝状态及肾功能的作用,能延缓糖尿病肾瘸的进展。
Objective: To investigate the effect of Ozagrenue injection on early stage of lame kidney lame proteinuria and hypercoagulability. Methods: One hundred and ten patients with early diabetic nephropathy hospitalized in Department of Nephrology of our hospital were randomly divided into observation group (56 cases) and control group (54 cases). The observation group was treated with Ozagrel 250ml intravenous drip daily Times; control group only given conventional treatment, 15d for a course of treatment. Before and after treatment were measured blood glucose, clotting time, fibrinogen, platelet and other clinical indicators, the treatment effect of the two groups were compared. Results: The decrease of urinary protein in the observation group was statistically significant (P <0.05), and the changes of coagulation time and fibrinogen were statistically significant (P <0.05). Conclusion: Ozagrenal injection can reduce urinary protein, improve hypercoagulability and renal function in patients with early diabetic nephropathy, and delay the progression of diabetic nephropathy.