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目的:探索胃癌组织中成纤维细胞激活蛋白(FAP)的表达与肿瘤恶性生物学行为和预后的关系。方法:收集2009年2月至2011年4月在我院手术的胃癌患者60例,采用免疫组化法检测胃癌组织和正常胃组织中FAP的表达水平,并分析其与临床病理特征、预后的相关性。结果:FAP在肿瘤间质成纤维细胞胞质内阳性表达,胃癌组织与正常胃组织中FAP阳性细胞数平均值分别为32.80±19.3和0.41±0.21(P<0.01)。胃癌组织中FAP的表达水平与肿瘤的大小、分化程度及临床分期明显相关(P<0.05)。Kaplan-Meier分析显示FAP低表达组胃癌患者术后的生存时间明显高于高表达组,差异有显著统计学意义(P<0.05)。结论:FAP在胃癌的生长、侵袭和转移中发挥着重要作用,可能作为胃癌预后判断和治疗的一个的潜在靶点。
Objective: To explore the relationship between the expression of fibroblast activating protein (FAP) and the malignant behavior and prognosis of gastric cancer. Methods: Sixty gastric cancer patients who underwent surgery in our hospital from February 2009 to April 2011 were collected. The expression of FAP in gastric cancer tissues and normal gastric tissues was detected by immunohistochemistry. The expression of FAP in the gastric cancer tissues and normal gastric tissues was analyzed and compared with the clinicopathological features, prognosis Correlation. Results: FAP was positively expressed in the cytoplasm of tumor interstitial fibroblasts. The average number of FAP positive cells in gastric cancer tissues and normal gastric tissues were 32.80 ± 19.3 and 0.41 ± 0.21 (P <0.01), respectively. The expression of FAP in gastric cancer tissues was significantly correlated with tumor size, differentiation degree and clinical stage (P <0.05). Kaplan-Meier analysis showed that the survival time of gastric cancer patients with low FAP expression was significantly higher than that of high expression group (P <0.05). Conclusion: FAP plays an important role in the growth, invasion and metastasis of gastric cancer and may be used as a potential target for the judgment and treatment of gastric cancer prognosis.