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目的 :测定 3 2例脑出血后昏迷患者血浆、胃液神经肽Y(neuropeptideY ,NPY)含量 ,探讨其与脑出血严重程度的关系及脑出血对胃肠动力的影响。方法 :采用放免法动态测定 3 2例急性脑出血后昏迷患者血浆、胃液NPY含量 ,动态观察NPY水平在脑出血后昏迷组和正常对照组中的变化。结果 :不同部位脑出血后昏迷患者血浆、胃液NPY含量第1周显著高于正常对照组 (P <0 .0 0 1) ,发病第 1天开始上升 ,第 2天达高峰 ,持续 3～ 5天后逐渐下降 ,第 4周接近正常对照组水平 ,不同部位脑出血后昏迷患者血浆、胃液NPY含量LSD组间比较以基底节出血破入脑室、基底节、脑叶、脑干出血呈梯次分布。结论 :NPY参与急性脑出血后继发性病理、生理损害 ,动态测定脑出血后昏迷患者血浆、胃液NPY含量 ,有助于判断脑出血严重程度和分析潜在胃肠动力改变 ,为临床诊断、治疗和营养护理提供科学依据。
Objective: To determine the content of neuropeptide Y (NPY) in plasma and gastric juice in patients with coma after cerebral hemorrhage in 32 cases, and to explore its relationship with the severity of cerebral hemorrhage and the effect of cerebral hemorrhage on gastrointestinal motility. Methods: The radioimmunoassay was used to measure the content of NPY in plasma and gastric juice of 32 patients with coma after acute intracerebral hemorrhage. The change of NPY level in coma and normal control group was observed dynamically. Results: The levels of NPY in plasma and gastric juice after ICH were significantly higher in the first week than those in the normal control group (P0.01) Days after the decline, the first 4 weeks close to the normal control group, different parts of the coma after intracerebral hemorrhage in plasma and gastric juice NPY content LSD compared with basal ganglia hemorrhage into the basal ganglia, basal ganglia, brain lobes, brainstem hemorrhage were echelon distribution. CONCLUSIONS: NPY is involved in secondary pathological and physiological damage after acute intracerebral hemorrhage. The dynamic measurement of NPY in plasma and gastric juice in patients with coma after intracerebral hemorrhage can help to determine the severity of cerebral hemorrhage and analyze the potential gastrointestinal motility. Nutritional care to provide a scientific basis.