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目的探讨HPV18与不同级别宫颈上皮内瘤变、不同临床病理特征宫颈癌的关系。方法采用原位杂交法检测HPV18在60例宫颈癌和60例宫颈上皮内瘤变及10例正常宫颈组织中的表达情况。结果正常宫颈组织中未见HPV18表达,宫颈上皮内瘤变组(8%)和宫颈癌组(15%)发现有HPV18表达;HPV18与宫颈鳞癌肌层浸润深度及淋巴结转移密切相关(P<0.05),与临床分期、组织学分级无明显关系(P>0.05)。结论HPV18表达与否可能是预测宫颈癌患者转归的影响因素之一,可以将其作为判断宫颈癌生物学行为和预后的参考指标。
Objective To investigate the relationship between HPV18 and different grades of cervical intraepithelial neoplasia and different clinicopathological features of cervical cancer. Methods In situ hybridization was used to detect the expression of HPV18 in 60 cases of cervical cancer and 60 cases of cervical intraepithelial neoplasia and 10 cases of normal cervical tissue. Results No HPV18 expression was found in normal cervical tissue. HPV18 expression was found in cervical intraepithelial neoplasia group (8%) and cervical cancer group (15%). HPV18 was closely associated with the depth of myometrial invasion and lymph node metastasis (P < 0.05). There was no significant correlation between clinical stage and histological grade (P> 0.05). Conclusions The expression of HPV18 may be one of the influential factors in predicting the prognosis of patients with cervical cancer, which can be used as a reference index to judge the biological behavior and prognosis of cervical cancer.