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目的:探讨莪术(Curcuma wenyujin)对糖尿病肾病大鼠的保护作用。方法:Wistar大鼠40只,分为假手术组、模型组和莪术治疗组,利用肾切除和链脲佐菌素(streptozotocin,STZ,45 mg.kg-1 ip)诱导糖尿病大鼠模型并用莪术进行干预(3 g.kg-1.d-1 ig),观察肾脏病理学变化,检测血糖(glucemia,Glu)总胆固醇(total cholesteral,TC)、血肌酐(blood serum creatinine,Scr)、尿微量白蛋白及结缔组织生长因子(connective tissue growth factor,CTGF)在肾脏的表达变化。结果:模型组较假手术组Glu,TC,尿白蛋白排泄率明显增高(P<0.01),CTGF在肾组织中的表达显著增加(P<0.01),肾脏病理变化显著;而莪术治疗组上述指标较模型组显著减少(P<0.01),CTGF在肾组织中的表达显著降低(P<0.01),肾脏病理变化有明显改善。结论:莪术对糖尿病大鼠的肾脏有保护作用,可能与其抑制CTGF在肾组织中的表达有关。
Objective: To investigate the protective effect of curcuma wenyujin on diabetic nephropathy rats. Methods: Forty Wistar rats were randomly divided into sham-operation group, model group and Ezhu treatment group. Diabetic rats were induced by nephrectomy and streptozotocin (STZ, 45 mg.kg-1 ip) (3 g.kg-1.d-1 ig). The renal pathological changes were observed. The levels of total cholesteral glucose (TC), blood serum creatinine (Scr) Changes of albumin and connective tissue growth factor (CTGF) expression in the kidney. Results: Compared with the sham-operation group, the urinary albumin excretion rate of Glu, TC and urinary albumin in the model group were significantly increased (P <0.01) and the expression of CTGF in the kidney tissue was significantly increased (P <0.01) (P <0.01). The expression of CTGF in renal tissue was significantly decreased (P <0.01), and the renal pathological changes were significantly improved. Conclusion: Curcuma has a protective effect on the kidney of diabetic rats, which may be related to the inhibition of CTGF expression in the kidney.