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目的探讨丁夏止吐膏治疗化疗呕吐的疗效。方法采用自拟中药处方(半夏、公丁香、吴茱萸、生姜取汁或干姜等)制成贴脐膏药,命名为“丁夏止吐膏”。设计3个止吐方案,A方案单用丁夏止吐膏,B方案丁夏止吐膏配合格拉司琼,C方案单用格拉司琼。按照不同化疗周期应用止吐方案的顺序,分为ABC、CAB、BCA 3组,每组30例,采用自身对照方法观察疗效。结果 3方案总有效率分别为:A方案83.33%,B方案97.78%,C方案84.44%。总有效率:B方案与A、C方案比较,有较显著差异P<0.05;A、C两方案比较无显著差异,P>0.05;但显效率A方案明显低于B、C两方案,有显著差异,P<0.01。结论单用丁夏止吐膏治疗化疗呕吐有一定疗效,与格拉司琼合用能显著提高格拉司琼控制化疗呕吐的疗效。本药价格便宜,性价比高,制作简便,未发现毒副作用,故值得临床推广应用。
Objective To investigate the curative effect of Dingxia Zhitong cream in the treatment of chemotherapy vomiting. Methods Self-made Chinese medicine prescription (Pinellia tuber, clove, Evodia, ginger juice or ginger, etc.) made paste navel plaster, named “Ding Xia antiemetic cream.” Design three antiemetic programs, A program alone Dingxia antiemetic cream, B program Ding Xia antiemetic cream with granisetron, C program single granisetron. In accordance with the different cycles of chemotherapy antiemetic programs in order, divided into ABC, CAB, BCA 3 groups, 30 cases in each group, using its own control method to observe the effect. Results 3 The total effective rate of programs were: A program 83.33%, B program 97.78%, C program 84.44%. The total effective rate: B program and A, C program comparison, there is a significant difference P <0.05; A, C two programs no significant difference, P> 0.05; but significant efficiency program A significantly lower than the B, C two programs, there are Significant difference, P <0.01. Conclusion Single Xia Ding Zhixue cream for the treatment of chemotherapy vomiting have a certain effect, combined with granisetron can significantly improve the efficacy of granisetron in the control of chemotherapy vomiting. The drug is cheap, cost-effective, easy to make, did not find any side effects, it is worthy of clinical promotion and application.