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目的:评价替比夫定对妊娠期孕妇伴有乙型肝炎病毒感染分娩后抗病毒的疗效及其对新生儿的影响。方法:选取2015年5月—2016年5月间收治的乙型肝炎病毒携带孕妇60例,采用抓阄分组法将其分为A组和B组,每组30例;A组孕妇给予乙型肝炎免疫球蛋白与乙型肝炎疫苗联用治疗,B组孕妇在A组的基础上加用替比夫定干预治疗,比较两组孕妇用药后的血清HBV-DNA测得值和两组婴儿血清HBe Ag、HBV-DNA测得值。结果:分别用药后不同时间段,B组孕妇血清HBeAg、HBV-DNA测得值低于A组(P<0.05);分娩后不同时间段A组婴儿血清HBe Ag、HBV-DNA阳性率低于B组(P<0.05)。结论:采用乙型肝炎免疫球蛋白和乙型肝炎疫苗与替比夫定联用治疗乙型肝炎病毒携带孕妇,可缓解其心理压力,提高了病毒在母-婴间的阻断率,降低了在母-婴间的垂直传播概率。
OBJECTIVE: To evaluate the effect of telbivudine on the antiviral efficacy of telbivudine in pregnant women with gestational hepatitis B virus infection after delivery and its effect on neonates. Methods: Sixty pregnant women with hepatitis B virus who were admitted between May 2015 and May 2016 were selected and divided into group A and group B with 30 cases in each group by grasping method. Group A pregnant women were given hepatitis B Immunoglobulin combined with hepatitis B vaccine treatment, group B pregnant women in group A plus telbivudine intervention treatment, serum HBV-DNA levels after treatment in both groups were compared with the two groups of infant serum HBe Ag, HBV-DNA measured value. Results: The serum levels of HBeAg and HBV-DNA in group B were significantly lower than those in group A at different time points (P <0.05). The positive rates of serum HBeAg and HBV-DNA in group A at different time points after delivery were lower than those in group A Group B (P <0.05). Conclusions: Hepatitis B virus-carrying pregnant women treated with hepatitis B immunoglobulin and hepatitis B vaccine in combination with telbivudine can relieve their psychological stress and increase the rate of virus-to-infant block and reduce Probability of vertical transmission between mother and baby.