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目的分析男性少弱精子症和/或畸形精子症患者与染色体核型的关系,探讨男性不育的遗传学病因。方法 521例受试者经精液检测,临床诊断为中重度少弱精子症和/或畸形精子症的男性患者,抽取其外周静脉血进行染色体核型分析并分类总结。结果 521例患者的细胞遗传学结果中染色体异常者148例,占28.41%。染色体结构异常有21例/次,染色体数目异常者1例/次,染色体多态性147例/次。结论中重度少弱精子症和/或畸形精子症男性常伴有染色体异常,其中染色体多态性出现的比例较高值得关注;对少弱精子症和/或畸形精子症患者行人工辅助生殖技术之前,有必要进行染色体检查。
Objective To analyze the relationship between chromosomal karyotypes and male oligoasthenospermia and / or deformity spermatozoa and explore the genetic causes of male infertility. Methods A total of 521 male subjects with moderate to severe oligoasthenospermia and / or malformation spermatozoon were enrolled in this study. Their peripheral venous blood samples were taken for chromosome karyotype analysis and classification. Results 521 cases of cytogenetic findings in 148 cases of chromosomal abnormalities, accounting for 28.41%. Chromosome structural abnormalities in 21 cases / times, chromosomal abnormalities in 1 case / times, chromosome polymorphisms in 147 cases / times. Conclusions Chronic severe asthenospermia and / or deformity spermatozoa are often associated with chromosomal abnormalities in men, of which chromosomal polymorphisms are more likely to be of concern. For those patients with oligoasthenospermia and / or deformity spermatogenesis, artificial assisted reproductive technology Before, it is necessary to carry out chromosome examination.