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目的研究急性颅脑损伤患者心电图、血清淀粉酶、乳酸、N末端脑钠肽前体(NT-proBNP)、超敏C-反应蛋白(hsCRP)、超敏心肌肌钙蛋白T(hs-cTnT)的变化并探讨其临床意义。方法选取2014年1月至2016年1月收治的急性颅脑损伤患者102例,所有患者均于入院即刻及入院后1、3 d行24 h动态心电图检测,并给予各项血生化检查。结果入院即刻患者心电图、NT-proBNP异常率显著高于入院后1、3 d,且入院后1 d又显著高于入院后3 d;入院即刻患者淀粉酶、乳酸hs-CRP、hs-cTnT水平均显著高于入院后1、3 d,且入院后1 d又显著高于入院后3 d,差异均有统计学意义(P均<0.05)。结论急性颅脑损伤患者可能存在不同程度的心肌损伤,对患者血清淀粉酶、乳酸、NT-proBNP、hs-CRP的变化进行检测,可有助于了解病情、观察疗效以及预后判定,并有利于临床医生制定具有针对性的干预措施,减少患者心肌损伤。
Objective To study the changes of electrocardiogram, serum amylase, lactate, NT-proBNP, hsCRP and hs-cTnT in patients with acute craniocerebral injury Changes and to explore its clinical significance. Methods Totally 102 acute craniocerebral injury patients were admitted from January 2014 to January 2016. All patients were examined by Holter immediately after admission and at 1 and 3 days after admission. Results The abnormal electrocardiogram and NT-proBNP in patients immediately after admission were significantly higher than those on the first and third days after admission, and were significantly higher than those on the first day after admission (3 days and 3 days after admission). The amylase, lactate hs-CRP and hs-cTnT levels Were significantly higher than 1,3 d after admission, and 1 d after admission was significantly higher than 3 d after admission, the differences were statistically significant (P all <0.05). Conclusion The patients with acute craniocerebral injury may have different degrees of myocardial damage. The detection of serum amylase, lactate, NT-proBNP and hs-CRP in patients with acute brain injury may help to understand the condition, observe the curative effect and prognosis, Clinicians develop targeted interventions to reduce myocardial damage in patients.