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目的研究静脉尿激酶溶栓治疗对急性心肌梗死患者运动耐量的影响。方法 90例急性心肌梗死患者分为溶栓再通组(25例)、未通组(20例)和非溶栓组(45例),比较三组急性期和远期运动耐量。结果急性期,再通组的运动耐量指标明显高于未通组和非溶栓组(P<0.05),运动诱发的心绞痛或血压下降≥10 mm Hg的比率明显低于后两者(P<0.05)。远期随访,三组的运动耐量指标及运动诱发心绞痛或血压下降的比率均无显著性差异(P>0.05)。结论尿激酶溶栓再通能显著提高急性心肌梗死患者急性期运动耐量,但对远期运动耐量改善不明显。
Objective To investigate the effect of intravenous urokinase thrombolytic therapy on exercise tolerance in patients with acute myocardial infarction. Methods Ninety patients with acute myocardial infarction were divided into thrombolytic group (n = 25), untreated group (n = 20) and non-thrombolytic group (n = 45). The acute and long-term exercise tolerance were compared between the three groups. Results During the acute phase, the indexes of exercise tolerance in the recanalization group were significantly higher than those in the non-through and non-thrombolytic groups (P <0.05). The rates of angina or blood pressure drop ≥10 mm Hg in exercise-induced recanalization were significantly lower than those in the latter two groups (P < 0.05). Long-term follow-up, exercise tolerance index and exercise-induced angina or decreased blood pressure in the three groups showed no significant difference (P> 0.05). Conclusion Urokinase thrombolytic recanalization can significantly improve exercise tolerance in patients with acute myocardial infarction, but not improve long-term exercise tolerance.