Objective: To explore the clinical effect of ambroxol hydrochloride combined with rehabilitation training on COPD and its effect on pulmonary function. Methods: 92 patients with COPD from May 2017 to may 2019 were randomly divided into control group (n = 46) and observation group (n = 46). The control group was treated with oxygen inhalation, expectorant, antispasmodic, anti infection and so on. The observation group was treated with ambroxol hydrochloride combined with rehabilitation training on this basis. Blood gas, lung function and inflammatory factors were compared before and after treatment. Results: the levels of SaO2 and PaO2 in the two groups were significantly higher than those before treatment (P There was significant difference between the two groups (P < 0.05-0.01). Besides, the level of lung function related indexes in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: ambroxol hydrochloride combined with rehabilitation training has a significant clinical effect on COPD, which can effectively improve the blood gas index and reduce the level of blood gas inflammatory factors, thus affecting the lung function of COPD patients.