复制高糖、高脂动物模型，利用血管功能测定、组织培养和放射免疫分析等方法观察长期高糖、高 脂血症对血管内皮细胞和平滑肌细胞功能的影响及相互作用。结果表明，高糖、高脂对血管内皮细胞均有影 响，两者有协同作用；对血管平滑肌细胞两者均可促进其增殖，加速了糖尿病血．管并发症的发生发展。 The effects of long-term high glucose and hyperlipidemia on the function and interaction of vascular endothelial cells and smooth muscle cells were observed by means of vascular function test, tissue culture and radioimmunoassay. The results showed that both high glucose and high fat had an effect on vascular endothelial cells, both of which had synergistic effect. Both of them could promote the proliferation of vascular smooth muscle cells and accelerate the blood of diabetic. The occurrence and development of tube complications.