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目的探讨血栓通联合尼可地尔治疗老年不稳定性心绞痛(UAP)的临床疗效及对患者氧化应激的影响。方法选取2014年1月至2015年10月新疆维吾尔自治区胸科医院心血管内科收治的96例符合标准的老年UAP患者作为研究对象,按随机数字表法分为对照组(n=48)和观察组(n=48),所有入选患者均给予常规药物治疗。在此基础上,对照组患者给予尼可地尔治疗,观察组患者在对照组基础上联合给予血栓通注射液治疗。比较两组患者临床疗效、心绞痛发生频率、发作持续时间、氧化应激指标水平及不良反应发生情况。结果疗效评价后显示,观察组患者治疗总有效率(95.8%)明显高于对照组(81.2%),差异有统计学意义(P<0.05);治疗后,与对照组患者心绞痛发生频率[(4.3±1.4)次/周]相比,观察组患者[(2.2±1.2)次/周]减少;与对照组患者持续时间[(3.6±1.3)min]相比,观察组患者[(2.4±0.8)min]缩短;与对照组患者氧化应激指标氧化型低密度脂蛋白水平[(586.2±74.6)μg/L]相比,观察组患者[(541.9±70.5)μg/L]降低;与对照组患者丙二醛水平[(8.1±1.5)μmol/L)]相比,观察组患者[(6.4±1.2)μmol/L]降低;与对照组患者超氧化歧化酶水平[(72.4±9.2)×103 U/L]相比,观察组患者[(83.1±10.6)×103 U/L]升高,组间比较差异均有统计学意义(P<0.05)。治疗期间,对照组和观察组患者均无严重不良反应病例,对照组和观察组患者不良反应发生率分别为8.3%和14.6%,组间比较差异无统计学意义(P>0.05)。结论血栓通注射液联合尼可地尔治疗老年UAP疗效可靠,能够明显提高临床疗效,减少心绞痛发生频率,缩短心绞痛发作持续时间,减轻机体氧化应激,且不良反应轻微,值得临床进一步研究。
Objective To investigate the clinical efficacy of Xueshuantong combined with nicorandil in the treatment of senile patients with unstable angina pectoris (UAP) and its effect on oxidative stress. Methods A total of 96 elderly patients with senile UAP admitted to Department of Cardiology, Chest Hospital of Xinjiang Uygur Autonomous Region from January 2014 to October 2015 were selected and divided into control group (n = 48) and observation group Group (n = 48), all patients were given conventional drug treatment. On this basis, patients in the control group were treated with nicorandil. Patients in the observation group were treated with Xueshuantong Injection on the basis of the control group. The clinical efficacy, the frequency of angina pectoris, the duration of seizure, the level of oxidative stress and the incidence of adverse reactions were compared between the two groups. Results After the curative effect evaluation, the total effective rate (95.8%) in the observation group was significantly higher than that in the control group (81.2%), the difference was statistically significant (P <0.05); after treatment, the frequency of angina pectoris [ (2.2 ± 1.2) times / week in the observation group compared with that in the control group [(3.6 ± 1.3) min vs 4.3 ± 1.4) times / week (541.9 ± 70.5) μg / L] in the observation group was significantly lower than that of the control group ([586.2 ± 74.6] μg / L] (6.4 ± 1.2) μmol / L] in the observation group was significantly lower than that of the control group [(8.1 ± 1.5) μmol / L). Compared with the control group, the level of superoxide dismutase [(72.4 ± 9.2 (83.1 ± 10.6) × 103 U / L] in the observation group compared with the control group (P <0.05). The difference between the two groups was statistically significant (P <0.05). During the treatment, the patients in the control group and the observation group had no serious adverse reactions. The incidence of adverse reactions in the control group and observation group were 8.3% and 14.6% respectively, with no significant difference between the two groups (P> 0.05). Conclusion Xueshuantong injection combined with Nicorandil is effective in treating elderly UAP. It can significantly improve clinical curative effect, reduce the frequency of angina pectoris, shorten the duration of angina pectoris, reduce the oxidative stress, and the side effects are minor, so it is worth further clinical study.