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目的观察亮菌口服溶液减轻儿童白血病化疗毒副作用的临床疗效。方法选取临床确诊为急性白血病,并行正规化疗的120例患儿,随机抽取60例患儿为治疗组,化疗期间给予亮菌口服溶液,口服,每次2/3支,每日3次,另外60例患儿为对照组,给予单纯正规化疗。观察患儿化疗后的毒副反应,毒副反应按照“WHO化疗毒副作用分级标准”进行评估。结果治疗组患儿白细胞减少,谷丙转氨酶升高,恶心、呕吐的发生率低于对照组,两组比较差异有统计学意义(P<0.05)。而血小板减少、血红蛋白减少、腹泻、便秘、周围神经炎的发生率两组比较无统计学意义(P>0.05)。结论亮菌口服溶液可以减轻儿童白血病化疗的毒副作用。
Objective To observe the clinical efficacy of Liangzhai oral solution in reducing the toxic and side effects of chemotherapy for childhood leukemia. Methods A total of 120 children with clinically diagnosed acute leukemia and concurrent formal chemotherapy were enrolled in this study. Sixty children were selected randomly as the treatment group. Oral administration was given orally during the chemotherapy period, 2/3 of them were taken orally, three times a day. 60 cases of children as control group, given simple formal chemotherapy. Toxicities and side effects after chemotherapy in children were observed and evaluated in accordance with the classification criteria of toxic and side effects of chemotherapy by WHO. Results The incidence of leukopenia, elevated alanine aminotransferase, nausea and vomiting in the treatment group was lower than that in the control group. There was significant difference between the two groups (P <0.05). The thrombocytopenia, hemoglobin decreased, diarrhea, constipation, peripheral neuritis incidence was no significant difference between the two groups (P> 0.05). Conclusion Liang oral solution can reduce the toxic side effects of chemotherapy in children with leukemia.