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目的:探讨米非司酮保守治疗植入性胎盘的疗效。方法:对13例经临床及彩超证实为部分性植入胎盘患者,采用米非司酮保守治疗,50 mg次/,2次/d(空腹),连用3~6 d,同时给予促宫缩、抗感染治疗。观察其临床效果及不良反应。结果:12例停药后3 d查HCG呈明显下降;8~15 d阴道排出坏死胎盘组织;20~35 d阴道少量流血停止。产后42 d复查彩超子宫复旧良好,宫腔未见异常回声区,无明显不良反应。1例阴道分娩患者在保守治疗10 d后失去信心,即行手术治疗。结论:用米非司酮保守治疗部分性植入胎盘是安全有效的。
Objective: To investigate the efficacy of mifepristone conservative treatment of implanted placenta. Methods: Totally 13 cases of placenta accreted by clinical and color Doppler were treated with conservative treatment with mifepristone 50 mg twice daily for 3 ~ 6 days, , Anti-infective treatment. Observe its clinical effect and adverse reaction. Results: HCG was significantly decreased in 12 cases 3 days after drug withdrawal; necrotic placental tissue was excreted vaginally in 8-15 days; and vaginal bleeding was stopped in 20-35 days. After 42 days of post-operative ultrasound examination of uterine involution good, no abnormal uterine cavity echo, no significant adverse reactions. One case of vaginal delivery patients lost confidence after 10 days of conservative treatment, that is, surgical treatment. Conclusion: Partial conservative placental implantation with mifepristone is safe and effective.