目的在子宫颈癌高发区调查妇女生殖道高危型别人乳头瘤病毒(HPV)感染状况,探讨浓缩子宫颈癌高危人群的方法,为子宫颈癌的免疫和化学预防提供科学依据和人群基础。方法选取30～50岁的已婚妇女为对象。研究分两阶段进行,第一阶段为妇女自己取样检查法,签署知情同意书后,受检妇女在医师的指导下自己采集阴道分泌物,然后调查其人口学基本信息;第二阶段由医师进行直接取样。将收集到的子宫颈脱落细胞放入装有固定液的试管保存,应用第2代杂交捕获(HybridCapture2)试验进行HPVDNA检测。标本中检出的HPVDNA≥2.0pg/ml即为感染阳性。两份标本的检测结果中任一项阳性即认作感染阳性。数据用VFP软件两遍录入后,进行核对纠错,应用SPSS软件进行统计分析。结果共调查9683名妇女,人群顺从性为75.4%。该人群HPV感染率为27.5%,阳城县HPV感染率高于襄垣县(P<0.001)。不同年龄组(30～,35～,40～,45～50)的HPV感染率分别为24.5%、27.4%、28.2%、27.4%,经统计学检验无显著性差异(P=0.604)。山区HPV感染率显著高于半山区(P=0.001)。教育程度为非正式上过学、小学、初中、高中及以上妇女的HPV感染率分别为26.1%、26.6%、27.5%、30.0%,经统计学检验无显著性差异(P=0.106)。结论本研究是迄今国内规模最大的调查,人群顺从性较高,其 Objective To investigate the prevalence of human papillomavirus (HPV) in women with high risk of genital tract in high incidence area of ​​cervical cancer and explore the methods of concentrating high risk population of cervical cancer so as to provide scientific basis and population basis for the immunization and chemical prevention of cervical cancer. Methods 30-30-year-old married women as the object. The study was conducted in two stages. In the first stage, the women took samples of themselves and signed the informed consent. The women under examination under the guidance of the doctor collected vaginal discharge and then investigated the basic demographic information. The second stage was conducted directly by the physicians sampling. The collected cervical exfoliated cells were placed in a test tube containing a fixative solution and subjected to an HPVDNA assay using the HybridCapture 2 test. Samples detected in HPVDNA ≥ 2.0pg / ml is positive for infection. Two specimens of any positive test results that are considered positive for infection. Data were entered twice with VFP software, checked and error correction, the application of SPSS software for statistical analysis. Results A total of 9,683 women were surveyed, with a population compliance of 75.4%. The HPV infection rate in this population was 27.5%, and the HPV infection rate in Yangcheng County was higher than that in Xiangyuan County (P <0.001). The HPV infection rates of different age groups (30 ~ 35 ~ 40 ~ 45 ~ 50) were 24.5%, 27.4%, 28.2% and 27.4%, respectively. There was no significant difference (P = 0.604) by statistical test. HPV infection rate was significantly higher in mountainous area than in mountainous area (P = 0.001). The level of education was unofficial. The HPV infection rates of women in primary, middle school, high school and above were 26.1%, 26.6%, 27.5% and 30.0% respectively. There was no significant difference (P = 0.106) by statistical tests. Conclusion This study is by far the largest survey in the country with a high population compliance